Exclzyme-2AF Double-Strength Joint Formula

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Exclzyme vs. Exclzyme 2AF

Many people have asked the question, “What is the difference between full-strength Exclzyme and Exclzyme 2AF?” This is usually accompanied by, “Which one should I take?” When looking at the ingredients of the products side-by-side, the initial differences become very clear – Exclzyme 2AF has a more comprehensive blend of enzymes and assisting ingredients than Exclzyme. However, the two Exclzyme products were intentionally designed to be very similar. Both products are intended to support a healthy inflammatory response.

When first choosing an enzyme supplement, we at AST Enzymes recommend starting with the original full-strength Exclzyme.

Exclzyme has an excellent consumer acceptability profile – used safely for over 10 years, Exclzyme has demonstrated time and time again just how beneficial the anti-inflammatory properties of these proteolytic enzymes are. For many, relief from symptoms has been reported in as little as one bottle. However for some, the activity in full-strength Exclzyme may not be enough.

For those who struggle with severe inflammation and are looking for something more, AST Enzymes has the solution: Exclzyme 2AF.

Exclzyme 2AF is considered “extra-strength”, due to the additional nutrients and herbs included in the formula. Those who have tried full-strength Exclzyme for up to 3 months with varying success have found that making the switch to Exclzyme 2AF made the difference in their pain and inflammation management.

Exclzyme 2AF for Severe Joint Pain and Inflammation

Another significant difference between the two Exclzyme products is their intended activity. Exclzyme 2AF has been formulated with particular interest in addressing the pain and inflammation associated with the joints. By including various supporting nutrients such as vitamin C, B vitamins, calcium and folate, Exclzyme 2AF has an increased capacity for targeting cartilage repair, which is a key aspect of managing joint healing.*

The use of additional herbs in Exclzyme 2AF is another way this product has specific benefits to joint health. Boswellia, also known as Indian frankincense, has been used traditionally as an Ayurvedic herb for its anti-inflammatory properties.* Likewise, the active ingredient in turmeric has been shown to relieve pain associated with arthritis and help improve joint function.* Grape seed extract’s antioxidant capacity has also been attributed to reduced joint pain.*

If you have any additional questions about the differences between these two products, please feel free to contact us.

Research

Exclzyme 2AF Research

More than 15 different studies have been performed on Exclzyme, including a clinical trial to observe serrapeptase’s effect on pain and inflammation. The results may affirm German doctor and atherosclerosis specialist Dr. Hans Napier claim: “Serrapeptase is the miracle enzyme.”

Studies show Exclzyme:

• Reduces C-reactive protein levels
• Is a natural alternative to NSAIDs
• Improves sports injury recovery
• Improves range of motion for people with back problems

Exclzyme vs. NSAIDS
Complete resolution in less time

Exclzyme 2AF includes serrapeptase. Studies and research demonstrate serrapeptase is effective as an all-natural, non-toxic alternative to NSAIDs (Non-Steroid Anti-Inflammatory Drugs). Many people turn to NSAIDs such as aspirin, ibuprofen, and naproxen for temporary relief, but these drugs are known to cause serious damage to the intestinal lining (ulcers), kidneys, and liver. In fact, gastrointestinal complications from prolonged NSAID use is the primary cause for emergency room visits in the United States.

Exclzyme 2AF and Joint Pain
In addition to Serrapeptase, which can block pain-inducing chemicals involved in the inflammatory response, Exclzyme 2AF contains boswellia and turmeric. These herbs are traditionally and widely known for their anti-inflammatory properties. For antioxidant support, Exclzyme 2AF contains vitamin C, amla, rutin and grape seed extract.

1.     Patki M. Study of anti-inflammatory and analgesic efficacy of Exclzyme ™ EN. J Orthopedics. 1999; 33(4):157-170.

Enzyme Activity in Exclzyme®2AF Proprietary Blend

FAQ

What is systemic enzyme therapy?

Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing. Exclzyme 2AF is specially formulated for joint health, making it perfect for athletes and sports-related injuries.

What is a systemic proteolytic enzyme?

Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to an abnormal inflammation response, which is accompanied by increased pain. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.

 What is fibrin?

Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.

Are systemic enzymes anti-inflammatory drugs?

Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.

Why is it important to take Exclzyme 2AF on an empty stomach?

Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme 2AFwith food will compromise their absorption, as well as their effectiveness.

Does Exclzyme 2AF have an enteric coating?

Yes, the serrapeptase in Exclzyme 2AF is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.

Do you use phthalates in your enteric coating?

At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant, which means that it can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully.

Don’t let the name scare you.MAAC is a food-grade compound that is listed as Generally Recognized as Safe (GRAS) by the Food and Drug Administration (FDA).  In addition, the Environmental Protection Agency (EPA) conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.

Unlike CAP, MAAC is not under regulation by California Proposition 65, which states that the ingredient is found by the state of California to cause cancer, birth defects, or other reproductive harm. In fact, the European Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. This conclusion on the safety of MAAC is derived from the findings of well-cited research.

How long should I take Exclzyme 2AF before feeling results?

Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including:

• Height
• Weight
• Age
• Severity of symptoms
• Tolerance
• Time of administration (Better absorbed on an empty stomach)
• Adherence to regimen
• Nutritional state

What if I miss a dose?

Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.

Are there any side effects involved with Exclzyme 2AF?

The use of Exclzyme 2AF has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.

Can I take Exclzyme 2AFwith other systemic enzymes?

Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme 2AF and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.

Can I take Exclzyme 2AF with digestive enzymes?

Although digestive and systemic enzymes arenot contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.