Joint and Inflammation Support
90 Capsules: Now $59.99
Exclzyme-2AF Double-Strength Joint Formula
An Aching Affliction
When considering joint disorders such as rheumatoid arthritis and osteoarthritis, inflammation is a serious concern as it is known to worsen their symptoms. Chronic inflammation is localized in the joint capsule, creating pain upon movement and reducing the functionality of the appendage. If left untreated, these conditions can lead to bone degeneration and/or a build-up of fibrin - a protein molecule accumulate around damaged tissue -within the affected joint. Treating the inflammation is a crucial part of joint health maintenance.
Given the relative commonality of joint-related pain and inflammation, many turn to readily available over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, acetaminophen or ibuprofen for relief. While these drugs are effective for initial signs of inflammation like pain and swelling, they do not encourage the repair of damaged tissue. In fact, with prolonged use, they can even cause additional damage to the gastro-intestinal system.
Exclzyme® 2AF for Joint and Inflammation Support
Exclzyme 2AF features Peptizyme SP® brand serrapeptase. A systemic enzyme, serrapeptase passes through the small intestine into the bloodstream purifying the body of dead cells in and around damaged tissues. Used widely for its fibrinolytic properties, research and clinical studies consistently show serrapeptase can help break down non-living tissue that is often the result of the inflammatory process. By breaking down this old cellular debris, serrapeptase improves blood circulation in the affected area, allowing vital nutrients and building blocks to nourish new cells.*
In addition to Serrapeptase, which can block pain-inducing chemicals involved in the inflammatory response, Exclzyme 2AF contains boswellia and turmeric. These herbs are traditionally known for their anti-inflammatory properties and are widely used as an alternative therapy. For antioxidant support, Exclzyme 2AF contains vitamin C, amla, rutin and grape seed extract.
Exclzyme® 2AF Dosage
NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day.
Complementing your Exclzyme 2AF with additional serrapeptase can increase proteolytic activity, as well as increase positive effects on inflammation and provide faster recovery and healing from injury.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule.
Buy These Products Together and Save
Buy Floracor-GI with Exclzyme 2AF for Better Absorption. Start your systemic enzyme therapy the right way. Increase the effectiveness of systemic enzymes by taking Floracor-GI with Exclzyme together. Floracor-GI is a blend of probiotics and enzymes for optimal intestinal health and greater nutrient absorption.
Combining the intestinal cleansing formula of Floracor-GI with the powerful systemic enzymes in Exclzyme 2AF supports the body’s utilization of systemic enzymes, healthier joint function and inflammatory response.
1 Exclzyme 2AF (200 caps.) + 1 Floracor-GI (180 caps.) + 1 DigeSEB-GI (90 caps.)=
FREE DigeSEB-GI WITH PURCHASE! - A $29.99 VALUE
Complete AST Enzymes Line of Products
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any diseases.
All material on this website is for informational purposes only. Nothing contained on this website is intended to be used as a medical diagnosis or treatment. It should not be used in place of the advice of your physician or qualified healthcare provider.
Exclzyme vs. Exclzyme 2AF
Many people have asked the question, “What is the difference between full-strength Exclzyme and Exclzyme 2AF?” This is usually accompanied by, “Which one should I take?” When looking at the ingredients of the products side-by-side, the initial differences become very clear – Exclzyme 2AF has a more comprehensive blend of enzymes and assisting ingredients than Exclzyme. However, the two Exclzyme products were intentionally designed to be very similar. Both products are intended to support a healthy inflammatory response.
When first choosing an enzyme supplement, we at AST Enzymes recommend starting with the original full-strength Exclzyme.
Exclzyme has an excellent consumer acceptability profile – used safely for over 10 years, Exclzyme has demonstrated time and time again just how beneficial the anti-inflammatory properties of these proteolytic enzymes are. For many, relief from symptoms has been reported in as little as one bottle. However for some, the activity in full-strength Exclzyme may not be enough.
For those who struggle with severe inflammation and are looking for something more, AST Enzymes has the solution: Exclzyme 2AF.
Exclzyme 2AF is considered “extra-strength”, due to the additional nutrients and herbs included in the formula. Those who have tried full-strength Exclzyme for up to 3 months with varying success have found that making the switch to Exclzyme 2AF made the difference in their pain and inflammation management.
Exclzyme 2AF for Severe Joint Pain and Inflammation
Another significant difference between the two Exclzyme products is their intended activity. Exclzyme 2AF has been formulated with particular interest in addressing the pain and inflammation associated with the joints. By including various supporting nutrients such as vitamin C, B vitamins, calcium and folate, Exclzyme 2AF has an increased capacity for targeting cartilage repair, which is a key aspect of managing joint healing.*
The use of additional herbs in Exclzyme 2AF is another way this product has specific benefits to joint health. Boswellia, also known as Indian frankincense, has been used traditionally as an Ayurvedic herb for its anti-inflammatory properties.* Likewise, the active ingredient in turmeric has been shown to relieve pain associated with arthritis and help improve joint function.* Grape seed extract’s antioxidant capacity has also been attributed to reduced joint pain.*
If you have any additional questions about the differences between these two products, please feel free to contact us.
Exclzyme 2AF Research
More than 15 different studies have been performed on Exclzyme, including a clinical trial to observe serrapeptase’s effect on pain and inflammation. The results may affirm German doctor and atherosclerosis specialist Dr. Hans Napier claim: “Serrapeptase is the miracle enzyme.”
Studies show Exclzyme:
Exclzyme vs. NSAIDS
Exclzyme 2AF includes serrapeptase. Studies and research demonstrate serrapeptase is effective as an all-natural, non-toxic alternative to NSAIDs (Non-Steroid Anti-Inflammatory Drugs). Many people turn to NSAIDs such as aspirin, ibuprofen, and naproxen for temporary relief, but these drugs are known to cause serious damage to the intestinal lining (ulcers), kidneys, and liver. In fact, gastrointestinal complications from prolonged NSAID use is the primary cause for emergency room visits in the United States.
1. Patki M. Study of anti-inflammatory and analgesic efficacy of Exclzyme ™ EN. J Orthopedics. 1999; 33(4):157-170.
Enzyme Activity in Exclzyme®2AF Proprietary Blend
What is systemic enzyme therapy?
Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing. Exclzyme 2AF is specially formulated for joint health, making it perfect for athletes and sports-related injuries.
What is a systemic proteolytic enzyme?
Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to an abnormal inflammation response, which is accompanied by increased pain. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.
What is fibrin?
Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.
Are systemic enzymes anti-inflammatory drugs?
Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.
Why is it important to take Exclzyme 2AF on an empty stomach?
Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme 2AFwith food will compromise their absorption, as well as their effectiveness.
Does Exclzyme 2AF have an enteric coating?
Yes, the serrapeptase in Exclzyme 2AF is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.
Do you use phthalates in your enteric coating?
At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant, which means that it can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully.
Don’t let the name scare you.MAAC is a food-grade compound that is listed as Generally Recognized as Safe (GRAS) by the Food and Drug Administration (FDA). In addition, the Environmental Protection Agency (EPA) conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.
Unlike CAP, MAAC is not under regulation by California Proposition 65, which states that the ingredient is found by the state of California to cause cancer, birth defects, or other reproductive harm. In fact, the European Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. This conclusion on the safety of MAAC is derived from the findings of well-cited research.
How long should I take Exclzyme 2AF before feeling results?
Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including:
What if I miss a dose?
Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.
Are there any side effects involved with Exclzyme 2AF?
The use of Exclzyme 2AF has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.
Can I take Exclzyme 2AFwith other systemic enzymes?
Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme 2AF and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.
Can I take Exclzyme 2AF with digestive enzymes?
Although digestive and systemic enzymes arenot contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.
"…no hesitation recommending Exclzyme-2AF to both practitioners and clients"
"I began using Exclzyme 2AF and the results were astounding."
Other ingredients: Microcrystalline cellulose and cellulose (vegetarian capsule)
Directions: Take 1 to 2 capsules three times a day on an empty stomach. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children.
Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.
Free of pesticides, chemicals, preservatives, animal derivatives, dairy, lactose, yeast, fish or shellfish, peanuts, tree nuts, artificial sweeteners and colors.
All individual enzymes and probiotics are kosher-certified, and suitable for vegetarians and vegans.
Bioactive Protein Peptide System (BPPS®) is a proprietary manufacturing process featuring complementary bioactive peptides, ensuring greater enzyme stability, absorption and bio-availability.