Serrapeptase 80,000 SPU or 130,000 SPU
120 Caps. 80K SPU:
Serrapeptase Enteric Coated Serrapeptase
The Problem with Discomfort
Systemic enzymes are key to a healthy lifestyle. Processed food, exposure to environmental toxins and occasional illness cause the body to use up these enzymes, forcing it to work even harder to make these enzymes and use them in the many complex reactions that take place every moment in our bodies.
Many people reach for NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen and naproxen to address discomfort. They are effective but come with serious side effects such as gastric bleeding, joint/cartilage damage, disrupted metabolism, increased blood sugar, loss of bone and emotional disorders, among others. In July of 1998, The American Journal of Medicine stated the following about NSAID-related gastrointestinal and metabolic complications:
“Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone. The figures of all NSAID users would be overwhelming, yet the scope of this problem is generally under-appreciated.”
An all-natural systemic enzyme, serrapeptase is a catalyst that stimulates and alters the body’s own capacity to recover with minimal side effects.
Serrapeptase (Peptizyme-SP®) for Healthy Fibrin Metabolism
How do SU’s relate to IU’s?
IU or SU is used interchangeably on different serrapeptase products. While we do not know what sort of assays other companies use to test their enzymes, you can still compare the activity level on a one-to-one basis. Unlike other supplements, the weight (mg) of an enzyme supplement carries no significance. It is not the amount but the potency, or activity, of the enzyme that really matters. Guaranteeing the ingredients are available to the body is more important than how much of the ingredient is listed on a supplement label.
NOTE: It is important to continue “therapeutic doses” until results are seen. This should then be reduced to a “maintenance dose” of 1-3 capsules two times a day.
Serrapeptase (Peptizyme-SP®)can be used along with other systemic enzyme blends such as Exclzyme or Serracor-NK to support fibrinolytic activity and mucus viscosity in the respiratory system.* This trademark is an absolute guarantee of quality.
Complete AST Enzymes Line of Products
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any diseases.
All material on this website is for informational purposes only. Nothing contained on this website is intended to be used as a medical diagnosis or treatment. It should not be used in place of the advice of your physician or qualified healthcare provider.
Peptizyme-SP vs. Serrétia**
Enteric Coating Comparison
*AST Enzymes uses MAAC as enteric coating
What is enteric coating, and why is it needed?
Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects.
What’s enteric coating made of?
At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully.
Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, the European Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements.
Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.
Serrapeptase Units: Facts OR Fiction?!
The units of Serrapeptase seem to be quite controversial in the market of enzymes today1. To truly understand these units let us gather a bit of knowledge to actually understand how enzymes work. The enzyme unit (U) is a unit for the amount of a particular enzyme. One U is defined as the amount of the enzyme that produces a certain amount of enzymatic activity, that is, the amount that catalyzes the conversion of 1 micro mole of substrate per minute.2 Enzyme activity is equal to the moles of substrate converted per unit of time under standard conditions. An increased amount of substrate will increase the rate of reaction with enzymes; however, once the reaction exceeds a certain point Vmax, the rate of reaction will become linear because the amount of active sites will remain constant.
Figure: 1 the above figure illustrates a Michaellis Menten Plot. This shows that an increase in substrate will increase the reaction rate until a certain point is reached (Vmax) then it will level off constant as all of the active sites have remained constant.
Now that we understand how an enzyme works on a biochemical level, how do we measure the units of activity specifically for Serrapeptase and what do they mean? If you have been researching the wide variety of options for Serrapeptase on the market today you have surely come across an extensive list of units that seem to leave people even more distraught then when they started. A shortlist would include mg, IU, SU and SPU. Let us explore each of these units and analyze them thoroughly in detail.
The first unit you may be familiar with and come across is mg, also known as milligrams. This is an accurate unit of measurement for weight; however, a weight of enzyme can contain low activity levels or high activity levels. Ideally for the highest quality enzyme, you would want the lowest weight and the highest activity ensuring purity. This is why we do not look at Serrapeptase in regards to mg weight like we would do with traditional NSAIDs, (anti-inflammatory drugs such as Aspirin, etc). Instead, the activity level of the enzyme is what is vital to it’s effectiveness in measure.
Another form of measurement, the International Unit, (IU), has also been seen on the market to describe the activity of Serrapeptase. The international unit is a unit of measurement for the amount of substance; mass or volume that constitutes one international unit caries based on the substance being measured. IU is supposed to be used to quantify vitamins, hormones, some medications, vaccines, and blood products. “The enzyme unit should not be confused with the international Unit (IU), and unrelated measure of biologically active substances.”6 Despite its name, IU is not part of the International System of Units physics and chemistry. “The IU should not be confused with the enzyme unit, also known as the International unit of enzyme activity and abbreviated as U.4” Companies that continue to use this unit (IU) to describe the activity of Serrapeptase are incorrect.
Finally, you may have come across (SU) or (SPU), both standing for Serrapeptase Unit and have been used interchangeably by the masses. These have both been accepted and accurate in industry; however, (SU) may draw some confusion. (SU) is a unit used in the digestion of Invertase (Sucrase). One SU (Sumner Unit Invertase/Sucrase) is the FCC assay of measurement, whereby one Sumner Unit is the quantity of enzyme that will convert 1 mg of sucrose to glucose and fructose in 5 minutes. As you can see this can become problematic using the same units for different processes already defined.7 While both SU and SPU are used today in industry, the most accurate unit to describe the activity of Serrapeptase is (SPU).
As a final point in summary, the potency of the enzyme is the most crucial factor in determining how well it will work, and this is measured by activity not by weight. The most accurate unit of measure for Serrapeptase is (SPU), Serrapeptase Units. Using this one and only Unit will assure that the information is accurate and streamline. Do not be fooled by marketing strategies of large incorporations to fool you by lack of knowledge as a consumer.
Don’t be misled by deceiving marketing strategies by other companies claiming to have serrapeptase with 250,000 SPU. These clever companies are misleading their customers to believe that they have the strongest Serrapeptase by claiming that their products contain 250,000 SPU of serrapeptase per “dosage”—which in most cases, 2 capsules, therefore only 125,000 per capsule. Don’t let yourself be fooled by deceptive techniques that are designed to confuse customers. AST Enzymes is the largest manufacturer of Serrapeptase in the world and happens to carry the strongest Serrapeptase on the market with 130,000 SPU per capsule! Our quality and prices of our products speak for themselves.
Our serrapeptase is enteric coated to survive the acidic conditions of the stomach without being degraded. This allows for optimum absorption in the small intestine and greater systemic activity. The pH resistant enteric coating disintegrates after it enters the alkaline environment of the intestine.
Most serrapeptase brands on the market are not enteric coated, which means this low-pH sensitive enzyme can lose activity, and thus effectiveness, when entering the stomach. The enteric coating in Serrapeptase allows the enzymes to survive the acidic conditions of the stomach, which increases absorption in the small intestine, systemic activity and efficacy.
2) Principles of Biochemistry, page 94, 4th Edition, Lehninger.
5) Canadian Society of Clinical Chemists (Dec 1992). "Canadian Society of Clinical Chemists position paper: standardization of selected polypeptide hormone measurements.". Clin Biochem. 25 (6): 415–24. doi:10.1016/0009-9120(92)90030-V. PMID 1477965.
** Serrétia™ and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.
Serrapeptase has been thoroughly researched for its numerous and diverse effects on the immune response.
Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1
A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing the symptoms in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2
A prospective study was conducted on the effect of serrapeptase on post-operative swelling and pain of the ankle. In the serrapeptase group, the swelling decreased by 50% on the third post-operative day, while in the control groups (no treatment and treatment with ice) no reduction in swelling occurred. A decrease in pain correlated for the most part with the reduction in swelling. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.3
The efficacy of serrapeptase was evaluated in a multicenter, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and acts rapidly on localized areas.4
Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.5
An unusual clinical trial evaluated the effectiveness of serratiopeptidase in the eradication of a periprosthetic infection (an infection at the site of an implanted orthopedic device) in an in vivo animal model. Infections of slime-forming bacteria are especially difficult at these sites. Rats were inoculated with Staphylococcus epidermidis at the prosthetic site. After two weeks, infection persisted in 63.2% of animals in the no-treatment group; 37.5% of animals in an antibiotic-only group; and only 5.6% of animals in the serratiopeptidase-and-antibiotic group. The authors conclude that serratiopeptidase was effective at eradicating infection in this experimental animal model and may enhance antibiotic efficacy in the treatment of staphylococcal infections.6
What is systemic enzyme therapy?
Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.
What is a systemic proteolytic enzyme?
Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.
What is fibrin?
Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.
Are systemic enzymes anti-inflammatory drugs?
Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.
Why is it important to take Peptizyme-SP on an empty stomach?
Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Peptizyme-SP with food will compromise their absorption, as well as their effectiveness.
Does Peptizyme-SP have an enteric coating?
Yes, the serrapeptase in Peptizyme-SP is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.
Do you use phthalates in your enteric coating?
No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.
To learn more about enteric coating used in AST Enzymes products, please see our “Compare” tab.
How long should I take Peptizyme-SP before feeling results?
Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After one week of proven tolerance, the dose can be increased to a therapeutic dose of 2 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 6 to 9 capsules per day, while others only need 2 to 3. There are several factors that may affect results and required dosage, including:
Severity of symptoms
Time of administration (Better absorbed on an empty stomach)
Adherence to regimen
What if I miss a dose?
Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.
Are there any side effects involved with Peptizyme-SP?
The use of Peptizyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.
Can I take Peptizyme-SP with other systemic enzymes?
Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products Peptizyme-SP and Serracor-NK often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.
Can I take Peptizyme-SP with digestive enzymes?
Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.
Other ingredients: Microcrystalline cellulose and cellulose (vegetarian capsule)
Other ingredients: Microcrystalline cellulose and cellulose (vegetarian capsule)
Directions: Take 1 to 2 capsules twice a day on an empty stomach. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children.
Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.
Free of pesticides, chemicals, preservatives, animal derivatives, dairy, lactose, yeast, fish or shellfish, peanuts, tree nuts, artificial sweeteners and colors.
All individual enzymes and probiotics are kosher-certified, and suitable for vegetarians and vegans.
Bioactive Protein Peptide System (BPPS®) is a proprietary manufacturing process featuring complementary bioactive peptides, ensuring greater enzyme stability, absorption and bio-availability.