Enteric Coated Serrapeptase and Nattokinase

Certain websites and distributors have recently claimed that enzymes do not require a pH resistant coating – known as an enteric coating – to be effective systemically. The fact is that all enzymes have a pH range. At the extremes of this range, whether acidic or alkaline, systemic enzymes will denature (become irreversibly inactive). While it’s true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial source systemic enzymes are less tolerant of a low pH.

Serrapeptase, one of the leading systemic enzymes available, originates from a bacteria that resides in the gut of silkworms – not from any fruit, vegetable, or bacteria that can survive on its own. Since it’s derived from a symbiotic organism (one that depends on another to exist), serrapeptase is a fragile enzyme. Yet, thanks to the technical advancements in microbiology, we have been able to isolate this enzyme for therapeutic use in humans.

Serrapeptase’s sole role in the gut of the silkworm is to assist it in emerging from its cocoon. Although serrapeptase is produced in the gut of the silkworm, its ultimate effect is breaking down the cocoon, not food matter. Likewise, as a systemic enzyme, serrapeptase is not used to breakdown food particles, but to act throughout the body to breakdown proteins like fibrin – a major protein factor involved in inflammation.

Likewise, nattokinase is an enzyme extracted and purified from the beneficial bacteria Bacillus natto (sometimes referred to as Bacillus subtilis natto) that is commonly found in the Japanese dish called natto, or fermented soy beans. This enzyme that’s used to make natto demonstrates powerful fibrinolytic activity within the bloodstream; thus, its ability to be absorbed intact from the gastrointestinal tract into the circulatory system requires significant consideration.

Because we are the actual manufacturer of our enzymes, AST Enzymes tests the products for both pH and temperature stability. Based on the results of kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with that of the stomach.

For maximum effectiveness, the serrapeptase and nattokinase in our products are enteric coated. In this way, we can ensure that these enzymes do not act on the contents in the stomach, or do not themselves become destroyed. Instead, our serrapeptase and nattokinase are able to reach the small intestine undamaged, where they can be readily absorbed into the circulatory system and delivered throughout the body to act therapeutically as intended.

AST Enzymes has 50 years of enzyme manufacturing experience to back up the claims we make. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme-SP® (enteric coated serrapeptase), NattoSEB® (enteric coated nattokinase), and SEBkinase® (a blend of Peptizyme-SP® and NattoSEB®, as found in Serracor-NK™). Our experience and expertise has led to an entire line of enteric coated enzymes that are able to reach the small intestine with higher activity for full systemic enzyme therapy.

Enzyme therapy is only as good as the enzymes that actually reach the areas of inflammation. When choosing systemic enzyme products, why settle for less? For the highest quality assurance, choose AST Enzymes products today.